How Exatype Works

1

Quality Control

Next-generation sequencing reads are trimmed of low-quality bases, and short or otherwise inferior reads are discarded.

2

Reference Mapping

Examap, a novel, codon-aware reference mapping tool, uses an assembly-free approach to map sequence reads to one or more reference sequences while considering both sequencing error and true diversity.

3

Mutation Calling

Mutations are called in each individual read. The Examap algorithm allows mutations to be called with >99% per-read accuracy.

4

Resistance Testing

Relevant genes and mutations, if present at sufficient prevalence, are analysed using accurate drug resistance testing algorithms.